BDBM50117271 1-(2,6-dimethylphenoxy)-2-propanolamine::1-(2,6-dimethylphenoxy)propan-2-amine::2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine::2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine(mexiletine)::CHEMBL558::MEXILETINE::Mexitil
SMILES CC(N)COc1c(C)cccc1C
InChI Key InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50117271
Affinity DataKi: 1.30E+4nMAssay Description:Binding affinity to inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+7nMAssay Description:Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of mouse NaV1.7 by IonWorks quattro automated electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human NaV1.7 by IonWorks quattro automated electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibition of fully inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair